Pivotal role of orexin signaling in the posterior paraventricular nucleus of the thalamus during the stress-induced reinstatement of oxycodone-seeking behavior

The results indicate that OXR signaling in the pPVT is critical for stress-induced reinstatement of oxycodone seeking, further corroborating OXRs as treatment targets for opioid use disorder.

Jessica M Illenberger, Francisco J Flores-Ramirez, Glenn Pascasio, Marissa Franco, Brandon Mendonsa, Rémi Martin-Fardon. Pivotal role of orexin signaling in the posterior paraventricular nucleus of the thalamus during the stress-induced reinstatement of oxycodone-seeking behavior. Journal of Psychopharmacology, 2024; DOI: 10.1177/02698811241260989

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