New brain targets for cocaine addiction

https://medicalxpress.com/news/2023-10-cellular-atlas-amygdala-reveals-treatment.html

Researchers at University of California San Diego School of Medicine and the Salk Institute for Biological Studies have created a unique, cell-by-cell atlas of the amygdala, a small structure deep within the brain that plays a crucial role in controlling emotional responses to drugs. The findings, published in Nature Neuroscience, helped the researchers identify a potential new treatment for cocaine addiction, a disease that is poorly understood at the molecular level and has virtually no approved pharmacological treatments.

Zhou, J.L. et al. Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in gene amygdala GABAergic inhibition. Nature Neuroscience(2023). DOI: 10.1038/s41593-023-01452-y www.nature.com/articles/s41593-023-01452-y

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