AUD Risk, Diagnoses, and Course in a Prospective Study Across Two Generations: Implications for Prevention

Alcohol Research:  Current Reviews v. 42, issue 1, 2022

Marc A. Schuckit

"One crucial tool for identifying factors that influence alcohol consumption and its consequences are longitudinal studies that follow individuals over long periods of time, sometimes including evaluating family members over several generations. Among the most important alcohol-related longitudinal studies are the San Diego Prospective Study (SDPS), the Collaborative Study on the Genetics of Alcoholism (COGA) and the Avon Longitudinal Study of Parents and Children (ALSPAC), each of which have been supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). This article briefly summarizes some findings from these studies, particularly the SDPS. After reviewing the contribution of genetic and environmental influences in AUD, it will introduce a low level of response (low LR) to alcohol as a risk factor for AUD. The article will then describe the 40-year SDPS in more detail, as well as its main conclusions regarding the contributions of genes and environment on the low LR and AUD, and summarizes an AUD prevention program based on the low LR."

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