Non-fatal drug overdoses are not benign and lead to neuropathological changes

 A vicious cycle of neuropathological, cognitive and behavioural sequelae of repeated opioid overdose.

Voronkov M, Ataiants J, Cocchiaro B, Stock JB, Lankenau SE.  Int J Drug Policy. 2021 Nov;97:103362. doi: 10.1016/j.drugpo.2021.103362. Epub 2021 Jul 24.
"Findings point to a vicious cycle of nonfatal overdose leading to neurodegeneration - closely resembling Alzheimer Disease - that results in cognitive decline that in turn leads to potentially reduced adherence to safe drug use behaviours."

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